Mindanao State University System is the only university in the Philippines with a special mandate of integrating the cultural communities, specially the Muslims into the mainstream of the nation's socio-cultural and political life by providing them with opportunities for quality and relevant public education for their self development and providing trained manpower skills and technical know-how for the economic development of the Mindanao, Sulu (Basilan and Tawi-Tawi) and Palawan region.

Mindanao State University System (MSUS) grew from one-campus University into a multi-campus University of seven (7) autonomous campuses and one (1) online campus, namely:

  Mindanao State University Main Campus - Marawi City, Lanao del Sur
  Mindanao State University Iligan Institute of Technology - Iligan City, Lanao del Norte
  Mindanao State University Naawan - Naawan, Misamis Oriental
 Mindanao State University Tawi-Tawi College of Technology and Oceanography - Bongao, Tawi-Tawi
 Mindanao State University Sulu - Jolo, Sulu
 Mindanao State University General Santos - General Santos City, South Cotabato
  Mindanao State University Maguindanao - Datu Odin Sinsuat, Maguindanao
 Mindanao State University Maigo School of Arts and Trade - Maigo, Lanao del Norte
  Mindanao State University Wisdom International Online